Substitute Edinson Cavani scored his sixth goal in four games as league leaders Paris St-Germain hit back to take a point at third-placed Reims.
The Champions looked to be heading for their first defeat of the season when teenager Theoson Siebatcheu put Reims ahead six minutes from time.
But a minute later Cavani fired home a low shot to take Paris a point clear of Rennes at the top of the table.
Cavani and recent signing Angel Di Maria both started on the Paris bench.
Coach Laurent Blanc brought the pair on with 25 minutes to go as his side looked to avoid failing to score for the first time since losing 2-0 to Barcelona in April's Champions League quarter-finals.
But it was Reims who went ahead when substitute Siebatcheu, 19, converted a pass from Nicolas de Preville with a shot into the bottom corner.
The lead lasted little more than 60 seconds, though, as Uruguay international Cavani, 27, calmly steered the ball home from 15 yards to claim his sixth goal of the season and secure a second successive draw for his side.