Exeter striker Tom Nichols has scored three goals this season
Exeter City ended early League Two leaders Leyton Orient's winning start to the season.
Tom Nichols put Exeter ahead from the spot after he was fouled by Charlie Grainger, before Alex Nicholls fired in from long range to double their lead.
Orient almost found their way back into the game but Matt Oakley cleared Jay Simpson's header off the line.
Nichols scored his second penalty when David Wheeler was brought down by Alan Dunne, before Wheeler sealed the win.